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Mechanistic Evidence of Pathophysiologic Target Besides the development of various efficient DPP-4 inhibitors and the demonstration that they have glucose-lowering properties, an important factor behind the concept of DPP-4 inhibition was that it targets the basic pathophysiological processes in type 2 diabetes

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Researchers continue to explore how these peptides, each operating through distinct biological mechanisms, may function together in experimental models focused on repair signaling, structural remodeling, angiogenesis-related pathways, and skin-associated biochemical processes